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Journal article

Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction.

Abstract:
Templated DNA strand ligation by the ring-strain promoted alkyne-azide [3+2] cycloaddition reaction is very fast; with dibenzocyclooctyne, the reaction is essentially complete in 1 min. It is inhibited by the presence of a single mismatched base pair suggesting applications in genetic analysis.
Publication status:
Published

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Publisher copy:
10.1039/c1cc10743g

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Communications
Volume:
47
Issue:
22
Pages:
6257-6259
Publication date:
2011-06-01
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Language:
English
Keywords:
Pubs id:
pubs:399990
UUID:
uuid:69aa415a-ee5a-4461-be60-39bcb2e87743
Local pid:
pubs:399990
Source identifiers:
399990
Deposit date:
2013-11-16

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