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H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH

Abstract:

Acid extrusion on Na+-coupled pH-regulatory proteins (pH-transporters), Na+/H+ exchange (NHE1) and Na+-HCO3- co-transport (NBC), drives Na+ influx into the ventricular myocyte. This H+-activated Na+-influx is acutely up-regulated at pHi<7.2, greatly exceeding Na+-efflux on the Na+/K+ ATPase. It is spatially heterogeneous, due to the co-localisation of NHE1 protein (the dominant pH-transporter) with gap-junctions at intercalated discs. Overall Na+-influx via NBC is considerably lower, but m...

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Publisher copy:
10.1016/j.yjmcc.2013.04.008

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of Molecular and Cellular Cardiology
Volume:
61
Pages:
51-59
Publication date:
2013-08-01
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Source identifiers:
415544
Language:
English
Keywords:
Pubs id:
pubs:415544
UUID:
uuid:69a022d4-3727-4284-bb77-b1c5be6d4cf6
Local pid:
pubs:415544
Deposit date:
2013-11-16

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