Journal article
H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
- Abstract:
-
Acid extrusion on Na+-coupled pH-regulatory proteins (pH-transporters), Na+/H+ exchange (NHE1) and Na+-HCO3- co-transport (NBC), drives Na+ influx into the ventricular myocyte. This H+-activated Na+-influx is acutely up-regulated at pHi<7.2, greatly exceeding Na+-efflux on the Na+/K+ ATPase. It is spatially heterogeneous, due to the co-localisation of NHE1 protein (the dominant pH-transporter) with gap-junctions at intercalated discs. Overall Na+-influx via NBC is considerably lower, but m...
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- Publisher copy:
- 10.1016/j.yjmcc.2013.04.008
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Bibliographic Details
- Journal:
- Journal of Molecular and Cellular Cardiology
- Volume:
- 61
- Pages:
- 51-59
- Publication date:
- 2013-08-01
- DOI:
- EISSN:
-
1095-8584
- ISSN:
-
0022-2828
- Source identifiers:
-
415544
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:415544
- UUID:
-
uuid:69a022d4-3727-4284-bb77-b1c5be6d4cf6
- Local pid:
- pubs:415544
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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