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Journal article

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity.

Abstract:

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA damage. Because the pathway may not be completely inhibited after blockade of PI3K itself, due to feedback through mammalian target of rapamycin (mTOR), more effective inhibition might be expected by targeting both PI3K and mTOR inhibition. MATERIALS AND METHODS: We investigated the effect of two dual PI3K/mTOR (both mTORC1 and mTORC2) inhi...

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Publication status:
Published

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Publisher copy:
10.1186/1748-717x-7-48

Authors


Yoshimura, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
Radiation oncology (London, England)
Volume:
7
Issue:
1
Pages:
48
Publication date:
2012
DOI:
EISSN:
1748-717X
ISSN:
1748-717X
URN:
uuid:699dab1f-b332-4803-b9c8-8429eabd109a
Source identifiers:
320452
Local pid:
pubs:320452

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