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Journal article

An early HIV mutation within an HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1.

Abstract:

Mutations within MHC class I-restricted epitopes have been studied in relation to T cell-mediated immune escape, but their impact on NK cells via interaction with killer Ig-like receptors (KIRs) during early HIV infection is poorly understood. In two patients acutely infected with HIV-1, we observed the appearance of a mutation within the B*57-restricted TW10 epitope (G9E) that did not facilitate strong escape from T cell recognition. The NK cell receptor KIR3DL1, carried by these patients, i...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00238-11

Authors


Journal:
Journal of virology More from this journal
Volume:
85
Issue:
11
Pages:
5415-5422
Publication date:
2011-06-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:127185
UUID:
uuid:698ea764-4ab9-4c86-9996-d5196b19f9c5
Local pid:
pubs:127185
Source identifiers:
127185
Deposit date:
2012-12-19

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