An early HIV mutation within an HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1.

Journal article

Mutations within MHC class I-restricted epitopes have been studied in relation to T cell-mediated immune escape, but their impact on NK cells via interaction with killer Ig-like receptors (KIRs) during early HIV infection is poorly understood. In two patients acutely infected with HIV-1, we observed the appearance of a mutation within the B*57-restricted TW10 epitope (G9E) that did not facilitate strong escape from T cell recognition. The NK cell receptor KIR3DL1, carried by these patients, i...

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Authors: Brackenridge, S; Evans, E; Toebes, M; Goonetilleke, N; Liu, M

• Publication status: Published
• Journal: Journal of virology
• Volume: 85
• Issue: 11
• Pages: 5415-5422
• Publication date: 2011-06-01
• DOI: 10.1128/jvi.00238-11
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Receptors, KIR3DL1; Surface Plasmon Resonance; HLA-B Antigens; Humans; Mutation, Missense; Immune Evasion; Amino Acid Substitution; Protein Binding; HIV-1; HIV Infections; Epitopes, T-Lymphocyte