Journal article
Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.
- Abstract:
-
The detection of tuberculosis currently relies upon insensitive and unspecific techniques; newer diagnostics would ideally co-opt specific bacterial processes to provide real-time readouts. The trehalose mycolyltransesterase enzymes (antigens 85A, 85B and 85C (Ag85A, Ag85B, Ag85C)) serve as essential mediators of cell envelope function and biogenesis in Mycobacterium tuberculosis. Through the construction of a systematically varied sugar library, we show here that Ag85 enzymes have exceptiona...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nchembio.539
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Authors
Bibliographic Details
- Journal:
- Nature chemical biology
- Volume:
- 7
- Issue:
- 4
- Pages:
- 228-235
- Publication date:
- 2011-04-01
- DOI:
- EISSN:
-
1552-4469
- ISSN:
-
1552-4450
- Source identifiers:
-
124325
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:124325
- UUID:
-
uuid:692fcc27-83a8-40ed-942c-143fcd636411
- Local pid:
- pubs:124325
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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