Journal article

Genomic and epidemiological surveillance of Zika virus in the Amazon region

Abstract:: Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. Until June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases were reported in Manaus city, Amazonas State, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, both in terms of transmission and viral genetic diversity. Using portable virus genome sequencing we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeast Brazil to Manaus. Spatial genomic analysis of virus movement among 6 areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. Those results might contribute to improve public health response to outbreaks in Brazil.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Giovanetti, M., Faria, N. R., Lourenco, J., Goes de Jesus, J., Xavier, J., Claro, I. M., Kraemer, M. U. G., Fonseca, V., Dellicour, S., Theze, J., da Silva Salles, F., Graef, T., Silveira, P. P., Costa de Souza, V., Alves do Nascimento, V., Campos de Melo Iani, F., Castilho-Martins, E. A., Cruz, L. N., Wallau, G., … Kastner, A. (2020). Genomic and epidemiological surveillance of Zika virus in the Amazon region. Cell Reports, 30(7), 2275–2283.e7.

MLA Style

Giovanetti, M, et al. “Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region.” Cell Reports, vol. 30, no. 7, 2020, pp. 2275–83.e7.

Chicago Style

Giovanetti, M, NR Faria, J Lourenco, et al. 2020. “Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region.” Cell Reports 30 (7): 2275–83.e7.
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Files:: CELL-REPORTS-D-19-02208_R3.pdf

(Preview, Accepted manuscript, pdf, 2.4MB, Terms of use)

Publisher copy:: 10.1016/j.celrep.2020.01.085

Authors

+ Giovanetti, M More by this author

Role:: Author

+ Faria, NR More by this author

Role:: Author

+ Lourenco, J More by this author

Role:: Author

+ Goes de Jesus, J More by this author

Role:: Author

+ Xavier, J More by this author

Role:: Author

More authors...

+ European Commission More from this funder

Grant:: 1341560

Publisher:: Cell Press
Journal:: Cell Reports More from this journal
Volume:: 30
Issue:: 7
Pages:: 2275-2283.e7
Article number:: February 2020
Publication date:: 2020-02-18
Acceptance date:: 2020-01-24
DOI:: 10.1016/j.celrep.2020.01.085
EISSN:: 2211-1247
ISSN:: 2211-1247

Language:: English
Keywords:: FFR
Pubs id:: 1084813
Local pid:: pubs:1084813
Deposit date:: 2020-02-04
ARK identifier:: ark:/29072/ora_692dab8f194344efb4aa41db6ad4dd1b

Terms of use

Copyright holder:: Giovanetti et al.
Copyright date:: 2020
Rights statement:: © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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