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Journal article

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Abstract:

ISG15 is an interferon-stimulated, ubiquitin-like protein that can conjugate to substrate proteins (ISGylation) to counteract microbial infection, but the underlying mechanisms remain elusive. Here, we use a virus-like particle trapping technology to identify ISG15-binding proteins and discover Ring Finger Protein 213 (RNF213) as an ISG15 interactor and cellular sensor of ISGylated proteins. RNF213 is a poorly characterized, interferon-induced megaprotein that is frequently mutated in Moyamoy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-26061-w

Authors


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Role:
Author
ORCID:
0000-0002-0007-5091
More by this author
Role:
Author
ORCID:
0000-0002-7348-0223
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
12
Issue:
1
Article number:
5772
Publication date:
2021-10-01
Acceptance date:
2021-09-14
DOI:
EISSN:
2041-1723
Pmid:
34599178
Language:
English
Keywords:
Pubs id:
1198434
Local pid:
pubs:1198434
Deposit date:
2022-01-04

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