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Early diagnosis of brain metastases through biofluid metabolomics

Abstract:

Over 20% of cancer patients develop brain metastases. Current MRI diagnostic techniques only detect late stage metastases, since they rely on blood-brain-barrier permeability to allow contrast enhancement. Thus, new methods enabling earlier diagnosis are urgently needed. We have previously shown that it is possible to discriminate between different inflammatory lesions in the CNS in rats (1), as well as between different stages of multiple sclerosis in patients (2), through biofluid (blood/ur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/neuonc/now292.010

Authors


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Institution:
University of Oxford
Division:
Oncology
Dickens, A More by this author
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Institution:
University of Oxford
Division:
Chemistry
Subgroup:
Organic Chemistry
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Institution:
University of Oxford
Division:
Pharmacology
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Institution:
University of Oxford
Division:
Oncology
Subgroup:
CRUK/MRC Ox Inst for Radiation Oncology
Publisher:
Oxford University Press Publisher's website
Volume:
19
Issue:
suppl_1
Pages:
i26-i27
Publication date:
2017-03-02
Acceptance date:
2016-06-27
DOI:
ISSN:
1523-5866 and 1522-8517
Pubs id:
pubs:719439
URN:
uri:6926bdb1-bb90-4549-beef-d43af29f2c17
UUID:
uuid:6926bdb1-bb90-4549-beef-d43af29f2c17
Local pid:
pubs:719439

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