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Early diagnosis of brain metastases through biofluid metabolomics

Abstract:

Over 20% of cancer patients develop brain metastases. Current MRI diagnostic techniques only detect late stage metastases, since they rely on blood-brain-barrier permeability to allow contrast enhancement. Thus, new methods enabling earlier diagnosis are urgently needed. We have previously shown that it is possible to discriminate between different inflammatory lesions in the CNS in rats (1), as well as between different stages of multiple sclerosis in patients (2), through biofluid (blood/ur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/neuonc/now292.010

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Institution:
University of Oxford
Division:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
British Neuro-Oncology Society Meeting 2016 (BNOS 2016) Journal website
Volume:
19
Issue:
suppl_1
Pages:
i26-i27
Host title:
Neuro-Oncology
Publication date:
2017-03-02
Acceptance date:
2016-06-27
DOI:
ISSN:
1523-5866 and 1522-8517
Source identifiers:
719439
Pubs id:
pubs:719439
UUID:
uuid:6926bdb1-bb90-4549-beef-d43af29f2c17
Local pid:
pubs:719439
Deposit date:
2018-10-30

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