- Abstract:
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Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegenerative disease mechanisms and emphasize the importance of asking appropriate research questions. In therapeutic studies, we suggest that understanding variability among and within mouse models is cr...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 448.8KB)
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(pdf, 43.5KB)
-
- Publisher copy:
- 10.1126/scitranslmed.aaq1818
-
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- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Translational Medicine Journal website
- Volume:
- 11
- Issue:
- 493
- Pages:
- Article: eaaq1818
- Publication date:
- 2019-05-22
- Acceptance date:
- 2018-06-19
- DOI:
- EISSN:
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1946-6242
- ISSN:
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1946-6234
- Pubs id:
-
pubs:908710
- URN:
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uri:6919e811-3b9e-428e-bfb6-b6b42d153fd8
- UUID:
-
uuid:6919e811-3b9e-428e-bfb6-b6b42d153fd8
- Local pid:
- pubs:908710
- Copyright holder:
- Fisher and Bannerman
- Copyright date:
- 2019
- Notes:
-
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: https://doi.org/10.1126/scitranslmed.aaq1818
Journal article
Mouse models of neurodegeneration: Know your question, know your mouse
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