Journal article
Mouse models of neurodegeneration: Know your question, know your mouse
- Abstract:
- Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegenerative disease mechanisms and emphasize the importance of asking appropriate research questions. In therapeutic studies, we suggest that understanding variability among and within mouse models is crucial for preventing translational failures in human patients.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 43.5KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 448.8KB, Terms of use)
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- Publisher copy:
- 10.1126/scitranslmed.aaq1818
Authors
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science Translational Medicine More from this journal
- Volume:
- 11
- Issue:
- 493
- Article number:
- eaaq1818
- Publication date:
- 2019-05-22
- Acceptance date:
- 2018-06-19
- DOI:
- EISSN:
-
1946-6242
- ISSN:
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1946-6234
- Pubs id:
-
pubs:908710
- UUID:
-
uuid:6919e811-3b9e-428e-bfb6-b6b42d153fd8
- Local pid:
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pubs:908710
- Source identifiers:
-
908710
- Deposit date:
-
2018-08-17
- ARK identifier:
Terms of use
- Copyright holder:
- Fisher and Bannerman
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: https://doi.org/10.1126/scitranslmed.aaq1818
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