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Mouse models of neurodegeneration: Know your question, know your mouse

Abstract:

Many mutant mouse strains have been developed as models to investigate neurodegenerative disease in humans. However, variability in results among studies using these mouse strains has led to questions about the value of these models. Here, we appraise various mouse models for dissecting neurodegenerative disease mechanisms and emphasize the importance of asking appropriate research questions. In therapeutic studies, we suggest that understanding variability among and within mouse models is cr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/scitranslmed.aaq1818

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-3024-7595
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
11
Issue:
493
Pages:
Article: eaaq1818
Publication date:
2019-05-22
Acceptance date:
2018-06-19
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pubs id:
pubs:908710
URN:
uri:6919e811-3b9e-428e-bfb6-b6b42d153fd8
UUID:
uuid:6919e811-3b9e-428e-bfb6-b6b42d153fd8
Local pid:
pubs:908710

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