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Targeted killing of pseudomonas aeruginosa by Pyocin G occurs via the Hemin Transporter Hur

Abstract:

Pseudomonas aeruginosa is a priority pathogen for the development of new antibiotics, particularly because multi-drug resistant strains of this bacterium cause serious nosocomial infections and are the leading cause of death in cystic fibrosis patients. Pyocins, bacteriocins of P. aeruginosa, are potent and diverse protein antibiotics that are deployed during bacterial competition. Pyocins are produced by more than 90% of P. aeruginosa strains and may have utility as last resort antibiotics a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2020.04.020

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Author
ORCID:
0000-0002-7028-1317
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Sub department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Author
Publisher:
Elsevier
Journal:
Journal of Molecular Biology More from this journal
Volume:
432
Issue:
13
Pages:
3869-3880
Publication date:
2020-04-24
Acceptance date:
2020-04-21
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Pmid:
32339530
Language:
English
Keywords:
Pubs id:
1102274
Local pid:
pubs:1102274
Deposit date:
2020-05-22

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