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Ni(2+) affects dopamine uptake which limits suitability as inhibitor of T-type voltage-gated Ca(2+) channels.

Abstract:

Neuronal T-type voltage-gated Ca(2+) channels are reported to have physiological roles that include regulation of burst firing, Ca(2+) oscillations, and neurotransmitter release. These roles are often exposed experimentally by blocking T-type channels with micromolar Ni(2+). We used Ni(2+) to explore the role of axonal T-type channels in dopamine (DA) release in mouse striatum, but identified significant off-target effects on DA uptake. Ni(2+) (100 μM) reversibly increased electrically evoked...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/cn500274g

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Publisher:
American Chemical Society Publisher's website
Journal:
ACS chemical neuroscience Journal website
Volume:
6
Issue:
1
Pages:
124-129
Publication date:
2015
DOI:
EISSN:
1948-7193
ISSN:
1948-7193
URN:
uuid:68d64312-5a1e-4c87-88c4-a9ebed9ea3b8
Source identifiers:
493494
Local pid:
pubs:493494

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