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Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells

Abstract:

Follicular dendritic cells (FDCs) regulate B cell function and development of high affinity antibody responses but little is known about their biology. FDCs associate in intricate cellular networks within secondary lymphoid organs. In vitro and ex vivo methods, therefore, allow only limited understanding of the genuine immunobiology of FDCs in their native habitat. Herein, we used various multicolor fate mapping systems to investigate the ontogeny and dynamics of lymph node (LN) FDCs in situ....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20132409

Authors


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Name:
Medical Research Council
Grant:
G0601156
Publisher:
Rockefeller University Press
Journal:
Journal of Experimental Medicine More from this journal
Volume:
211
Issue:
6
Pages:
1109-1122
Publication date:
2014-05-26
Acceptance date:
2014-04-14
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pmid:
24863064
Language:
English
Keywords:
Pubs id:
pubs:821770
UUID:
uuid:68ca3b41-c569-4ac0-a11c-ec4f18077ff8
Local pid:
pubs:821770
Source identifiers:
821770
Deposit date:
2019-10-31

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