Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling

Journal article

\ua9 2024 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article\u27s title, journal citation, and DOI.We consider the mean-field vortex solutions and their stability within a two-component Bose-Einstein condensate in the immiscible limit. A variational approach is employed to study a system consisting of a majority component which contains a single quantized vortex and a minority component which fills the vortex core. We show that a super-Gaussian function is a good approximation of the two-component vortex solution for a range of atom numbers of the infilling component by comparing the variational solutions to the full numerical solutions of the coupled Gross-Pitaevskii equations. We subsequently examine the stability of the vortex solutions by perturbing the infilling component away from the center of the vortex core, thereby demonstrating their stability to small perturbations. Finally, we consider the dynamics of infilled vortices

Authors: Šimelis, K; Saraç, H; Salah, E; Nishio, K; McAllister, TE

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Bioorganic & Medicinal Chemistry
• Volume: 99
• Pages: 117597-117597
• Article number: 117597
• Publication date: 2024-01-12
• DOI: 10.1016/j.bmc.2024.117597
• EISSN: 1464-3391
• ISSN: 0968-0896
• Language: English
• Keywords: Stereochemistry; Isozyme; Gene; Peptide; Computational biology; Profiling (computer programming); Biochemistry; Oxygenase; Biology; Epigenetics; Chemistry; Enzyme; Selectivity