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Coalescent estimates of HIV-1 generation time in vivo.

Abstract:

The generation time of HIV Type 1 (HIV-1) in vivo has previously been estimated using a mathematical model of viral dynamics and was found to be on the order of one to two days per generation. Here, we describe a new method based on coalescence theory that allows the estimate of generation times to be derived by using nucleotide sequence data and a reconstructed genealogy of sequences obtained over time. The method is applied to sequences obtained from a long-term nonprogressing individual at...

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Publisher copy:
10.1073/pnas.96.5.2187

Authors


Rodrigo, AG More by this author
Shpaer, EG More by this author
Delwart, EL More by this author
Iversen, AK More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
96
Issue:
5
Pages:
2187-2191
Publication date:
1999-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:68c9ced1-9ec0-446e-9c1e-bc127a3ba9de
Source identifiers:
68293
Local pid:
pubs:68293

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