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Analgesic use and risk of acute coronary events in patients with osteoarthritis: a population-based nested case-control study

Abstract:

Purpose: Recent controversies on the safety profile of opioids and paracetamol have led to changes in clinical guidance for osteoarthritis (OA) management. We studied the existing association between the use of different OA drug therapies and the risk of acute coronary events (ACE).

Methods: A cohort of patients with clinically diagnosed OA (according to ICD10 codes) was identified in the SIDIAP database. Within the cohort, cases with incident ACE (AIM or unstable angina) between 2...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.clinthera.2017.12.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-3950-6346
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Bioibérica S.A. More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Clinical Therapeutics Journal website
Volume:
40
Issue:
2
Pages:
270–283
Publication date:
2018-02-02
Acceptance date:
2017-12-14
DOI:
ISSN:
1879-114X
Source identifiers:
811286
Keywords:
Pubs id:
pubs:811286
UUID:
uuid:68bfd200-92c2-4262-b536-923461da4788
Local pid:
pubs:811286
Deposit date:
2017-12-15

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