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Relationships between the N-glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures.

Abstract:

Eight preparations of recombinant human erythropoietin (EPO) with differing isoform compositions were produced by using different culture conditions and purification procedures. The N-glycan structures of these EPOs were analysed using a recently developed profiling procedure and identified using matrix-assisted laser desorption ionization mass spectrometry. The specific activities of each of the EPOs were estimated by in vivo and in vitro mouse bioassays. The eight EPOs were found to differ ...

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Publication status:
Published

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Authors


Storring, PL More by this author
Tiplady, RJ More by this author
Izquierdo, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
British journal of haematology
Volume:
121
Issue:
3
Pages:
511-526
Publication date:
2003-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:68a4614e-4e4b-46c3-82ac-5c82125d0bfe
Source identifiers:
229140
Local pid:
pubs:229140

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