Journal article
Relationships between the N-glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures.
- Abstract:
-
Eight preparations of recombinant human erythropoietin (EPO) with differing isoform compositions were produced by using different culture conditions and purification procedures. The N-glycan structures of these EPOs were analysed using a recently developed profiling procedure and identified using matrix-assisted laser desorption ionization mass spectrometry. The specific activities of each of the EPOs were estimated by in vivo and in vitro mouse bioassays. The eight EPOs were found to differ ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- British journal of haematology
- Volume:
- 121
- Issue:
- 3
- Pages:
- 511-526
- Publication date:
- 2003-05-01
- DOI:
- EISSN:
-
1365-2141
- ISSN:
-
0007-1048
- Source identifiers:
-
229140
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:229140
- UUID:
-
uuid:68a4614e-4e4b-46c3-82ac-5c82125d0bfe
- Local pid:
- pubs:229140
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2003
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