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Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.

Abstract:

We show here that the cell cycle-dependent DNA-binding and transcriptional activity of p53 correlates with E2F expression in human primary fibroblasts. E2F1 binds and stimulates DNA-binding, transactivation and apoptotic functions of p53 but not p63 and p73. E2F1 binds residues 347-370 of p53 and enhances nuclear retention of Ser315 phosphorylated p53. This regulation of p53 by E2F1 is cell cycle dependent, as the cellular distribution of Ser315 phosphorylated p53 is associated with the perio...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7600735

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
The EMBO journal
Volume:
24
Issue:
15
Pages:
2768-2782
Publication date:
2005-08-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:68a13de0-c97c-4c2e-b485-b42308ce564b
Source identifiers:
83977
Local pid:
pubs:83977

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