Osteoclast-like cells in soft tissue leiomyosarcomas.

Journal article

Giant cell-rich leiomyosarcoma of soft tissues is an unusual variant of malignant smooth muscle tumor characterized by the presence of numerous multinucleated giant cells (MNGCs). The nature of MNGCs and the cellular mechanisms underlying their accumulation in this tumor are poorly understood. Analysis of the expression of osteoclast, macrophage, and smooth muscle markers in two cases of giant cell-rich leiomyosarcoma revealed that the MNGCs in giant cell-rich leiomyosarcoma were negative for...

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Authors: Gibbons, C; Sun, S; Vlychou, M; Kliskey, K; Lau, Y

• Publication status: Published
• Journal: Virchows Archiv : an international journal of pathology
• Volume: 456
• Issue: 3
• Pages: 317-323
• Publication date: 2010-03-01
• DOI: 10.1007/s00428-010-0882-z
• EISSN: 1432-2307
• ISSN: 0945-6317
• Language: English
• Keywords: Female; Osteoclasts; Macrophages; Adult; Humans; Leiomyosarcoma; TNF-Related Apoptosis-Inducing Ligand; RANK Ligand; Aged; Giant Cells; Soft Tissue Neoplasms; Male; Osteoprotegerin