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Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

Abstract:

Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1 and BD2 and forms a complex with the positive transcription elongation factor b, which controls phosphorylation of RNA polymerase II, ultimately leading to stimulation of transcription elongation. An essential role of BRD4 in cell proliferation and cancer growth has been reported in several recent studies. We analyzed ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.523019

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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
Journal of biological chemistry
Volume:
289
Issue:
13
Pages:
9304-9319
Publication date:
2014-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
462551

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