Nuclear chromosome locations dictate segregation error frequencies

Journal article

Chromosome segregation errors during cell divisions generate aneuploidies and micronuclei, which can undergo extensive chromosomal rearrangements such as chromothripsis [1, 2, 3, 4, 5]. Selective pressures then shape distinct aneuploidy and rearrangement patterns—for example, in cancer [6, 7] —but it is unknown whether initial biases in segregation errors and micronucleation exist for particular chromosomes. Using single-cell DNA sequencing [8] after an error-prone mitosis in untransformed, d...

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Authors: Klaasen, SJ; Truong, MA; van Jaarsveld, RH; Koprivec, I; Štimac, V

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature
• Volume: 607
• Issue: 7919
• Pages: 604-609
• Publication date: 2022-07-13
• DOI: 10.1038/s41586-022-04938-0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Mitosis; Interphase; Ploidy; Genetics; Genome; Chemistry; Chromosome segregation; Micronucleus test; Genome instability; DNA; Chromothripsis; Chromosome; Replication timing; Biology; Aneuploidy; DNA damage; Gene