Biology of ischemic cerebral cell death.

Journal article

With the approval of alteplase (tPA) therapy for stroke, it is likely that combination therapy with tPA to restore blood flow, and agents like glutamate receptor antagonists to halt or reverse the cascade of neuronal damage, will dominate the future of stroke care. The authors describe events and potential targets of therapeutic intervention that contribute to the excitotoxic cascade underlying cerebral ischemic cell death. The focal and global animal models of stroke are the basis for the id...

Expand abstract

Authors: Small, D; Morley, P; Buchan, A

• Publication status: Published
• Journal: Progress in cardiovascular diseases
• Volume: 42
• Issue: 3
• Pages: 185-207
• Publication date: 1999-01-01
• DOI: 10.1016/s0033-0620(99)70002-2
• EISSN: 1873-1740
• ISSN: 0033-0620
• Language: English
• Keywords: Cell Death; Humans; Free Radicals; Animals; Signal Transduction; Treatment Outcome; Thrombolytic Therapy; Fibrinolytic Agents; Brain Ischemia; Tissue Plasminogen Activator; Receptors, Glutamate; Excitatory Amino Acid Antagonists