Journal article
Circulating metabolites and the development of type 2 diabetes in Chinese adults
- Abstract:
-
Objective: To assess prospective associations of circulating metabolites with risk of type 2 diabetes (T2D) among Chinese adults.
Research Design and Methods: A case-cohort study within the 8-year prospective China Kadoorie Biobank comprised 882 incident cases of T2D and 789 subcohort participants. NMR metabolomic profiling quantified 225 metabolites in stored baseline plasma samples. Cox regression related individual metabolites with T2D risk, adjusting for potential confounders and fasting time.
Results: After correction for multiple testing, 163 metabolites were significantly associated with risk of T2D (p<0.05). There were strong positive associations of VLDL particle size, the ratio of apolipoprotein B/apolipoprotein A1, branched chain amino acids, glucose and triglycerides with T2D, and inverse associations of HDL-cholesterol, HDL particle size, and relative omega-3 and saturated fatty acid concentrations.
Conclusions: In Chinese adults, metabolites across diverse pathways were independently associated with T2D risk, providing valuable aetiological insights and potential to improve T2D risk prediction.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, 126.6KB, Terms of use)
-
- Publisher copy:
- 10.2337/dc21-1415
Authors
- Publisher:
- American Diabetes Association
- Journal:
- Diabetes Care More from this journal
- Volume:
- 45
- Issue:
- 2
- Pages:
- 477–480
- Publication date:
- 2021-11-30
- Acceptance date:
- 2021-11-09
- DOI:
- EISSN:
-
1935-5548
- ISSN:
-
0149-5992
- Language:
-
English
- Keywords:
- Pubs id:
-
1207726
- Local pid:
-
pubs:1207726
- Deposit date:
-
2021-11-10
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2021
- Rights statement:
- © 2022 by the American Diabetes Association https://www.diabetesjournals.org/content/license Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from American Diabetes Association at: https://doi.org/10.2337/dc21-1415
If you are the owner of this record, you can report an update to it here: Report update to this record