- Abstract:
-
In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 . Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to Sp1-induced T cell proliferation, a hallmark of thymus-dependent immune responses. We used peripheral blood mononuclear cells obtained from adults enrolled in a randomised clini...
Expand abstract - Publisher copy:
- 10.1016/j.imbio.2012.05.008
-
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- Journal:
- Immunobiology
- Volume:
- 218
- Issue:
- 3
- Pages:
- 368-372
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1878-3279
- ISSN:
-
0171-2985
- URN:
-
uuid:681a6bf5-276e-4828-ac72-58ed44897e4a
- Source identifiers:
-
384811
- Local pid:
- pubs:384811
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
The zwitterionic type I Streptococcus pneumoniae polysaccharide does not induce memory B cell formation in humans
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