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The zwitterionic type I Streptococcus pneumoniae polysaccharide does not induce memory B cell formation in humans

Abstract:

In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 . Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to Sp1-induced T cell proliferation, a hallmark of thymus-dependent immune responses. We used peripheral blood mononuclear cells obtained from adults enrolled in a randomised clini...

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Publisher copy:
10.1016/j.imbio.2012.05.008

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Journal:
Immunobiology
Volume:
218
Issue:
3
Pages:
368-372
Publication date:
2013-03-01
DOI:
EISSN:
1878-3279
ISSN:
0171-2985
Source identifiers:
384811
Language:
English
Keywords:
Pubs id:
pubs:384811
UUID:
uuid:681a6bf5-276e-4828-ac72-58ed44897e4a
Local pid:
pubs:384811
Deposit date:
2013-11-16

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