Journal article icon

Journal article

Human AGR2 deficiency causes mucus barrier dysfunction and infantile inflammatory bowel disease

Abstract:

Background & Aims
The gastrointestinal epithelium plays a crucial role in maintaining homeostasis with the gut microbiome. Mucins are essential for intestinal barrier function and serve as a scaffold for antimicrobial factors. Mucin 2 (MUC2) is the major intestinal gel-forming mucin produced predominantly by goblet cells. Goblet cells express anterior gradient 2 (AGR2), a protein disulfide isomerase that is crucial for proper processing of gel-forming mucins. Here, we... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.jcmgh.2021.07.001

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-6757-0436

Contributors

More from this funder
Name:
Wellcome Trust
Grant:
106169/Z/14/Z
Publisher:
Elsevier
Journal:
Cellular and Molecular Gastroenterology and Hepatology More from this journal
Volume:
12
Issue:
5
Pages:
1809-1830
Publication date:
2021-07-06
Acceptance date:
2021-07-01
DOI:
EISSN:
2352-345X
ISSN:
2352-345X
Pmid:
34237462
Language:
English
Keywords:
Pubs id:
1186560
Local pid:
pubs:1186560
Deposit date:
2021-08-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP