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N-cadherin orchestrates self-organization of neurons within a columnar unit in the Drosophila medulla

Abstract:

Columnar structure is a basic unit of the brain, but the mechanism underlying its development remains largely unknown. The medulla, the largest ganglion of the Drosophila melanogaster visual center, provides a unique opportunity to reveal the mechanisms of 3D organization of the columns. In this study, using N-cadherin (Ncad) as a marker, we reveal the donut-like columnar structures along the 2D layer in the larval medulla that evolves to form three distinct layers in pupal development. Colum...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/JNEUROSCI.3107-18.2019

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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/P031587/1
Publisher:
Society for Neuroscience
Journal:
Journal of Neuroscience More from this journal
Volume:
39
Issue:
30
Pages:
5861-5880
Publication date:
2019-07-24
Acceptance date:
2019-05-15
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
31175213
Language:
English
Keywords:
Pubs id:
1098227
Local pid:
pubs:1098227
Deposit date:
2020-04-07

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