Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.

Journal article

The forkhead transcription factor FoxM1 controls expression of a large number of genes that are specifically expressed during the G(2) phase of the cell cycle. Throughout most of the cell cycle, FoxM1 activity is restrained by an autoinhibitory mechanism, involving a repressor domain present in the N-terminal part of the protein. Activation of FoxM1 in G(2) is achieved by Cyclin A/Cyclin-dependent kinase (Cdk)-mediated phosphorylation, which alleviates autoinhibition by the N-terminal repress...

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Authors: Alvarez-Fernández, M; Halim, V; Aprelia, M; Laoukili, J; Mohammed, S

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 286
• Issue: 38
• Pages: 33029-33036
• Publication date: 2011-09-01
• DOI: 10.1074/jbc.m111.253724
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Cell Line; Cyclin A; Forkhead Transcription Factors; Humans; Protein Phosphatase 2; Molecular Sequence Data; Phosphorylation; Peptides; Protein Binding; Transcription, Genetic; Cyclin-Dependent Kinases; Amino Acid Sequence