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Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.

Abstract:

The forkhead transcription factor FoxM1 controls expression of a large number of genes that are specifically expressed during the G(2) phase of the cell cycle. Throughout most of the cell cycle, FoxM1 activity is restrained by an autoinhibitory mechanism, involving a repressor domain present in the N-terminal part of the protein. Activation of FoxM1 in G(2) is achieved by Cyclin A/Cyclin-dependent kinase (Cdk)-mediated phosphorylation, which alleviates autoinhibition by the N-terminal repress...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.253724

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Journal:
Journal of biological chemistry More from this journal
Volume:
286
Issue:
38
Pages:
33029-33036
Publication date:
2011-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:384559
UUID:
uuid:67e54e1f-0ecc-4738-9dbe-231cbeb413f0
Local pid:
pubs:384559
Source identifiers:
384559
Deposit date:
2013-11-16

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