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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Abstract:

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association studies and subsequent meta-analyses of these two diseases as separate phenotypes have implicated previously unsuspected mechanisms, such as autophagy, in their pathogenesis and showed that some IBD loci are shared with other inflammatory diseases. Here we expand on the knowle...

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Publisher copy:
10.1038/nature11582

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Journal:
Nature
Volume:
491
Issue:
7422
Pages:
119-124
Publication date:
2012-11-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
426338

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