Journal article icon

Journal article

Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders

Abstract:

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we perfo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1016/j.ajhg.2018.09.009

Authors


Ligthart, S More by this author
Stathopoulou, MG More by this author
De Vries, PS More by this author
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Human Genetics Journal website
Volume:
103
Issue:
5
Pages:
691-706
Publication date:
2018-11-01
Acceptance date:
2018-09-20
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Pubs id:
pubs:936931
URN:
uri:67b27470-dee9-495d-8078-9ca8954dd4e2
UUID:
uuid:67b27470-dee9-495d-8078-9ca8954dd4e2
Local pid:
pubs:936931

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP