Osteocyte recruitment declines as the osteon fills in: interacting effects of osteocytic sclerostin and previous hip fracture on the size of cortical canals in the femoral neck.

Journal article

There is little information on the distribution of osteocytes within the individual cortical osteon, but using direct 3-D imaging in a single subject, Hannah et al. found a gradient with a two-fold higher density of cells adjacent to the cement line compared to near the canal. Since a limiting factor for bone formation might be the availability of osteoblasts due to their recruitment as osteocytes, we studied distributions of osteonal osteocytes in frozen sections of the femoral neck cortex. ...

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Authors: Power, J; Doube, M; van Bezooijen, R; Loveridge, N; Reeve, J

• Publication status: Published
• Journal: Bone
• Volume: 50
• Issue: 5
• Pages: 1107-1114
• Publication date: 2012-05-01
• DOI: 10.1016/j.bone.2012.01.016
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Microscopy, Polarization; Cell Count; Genetic Markers; Male; Organ Size; Cell Death; Hip Fractures; Models, Biological; Humans; Female; Bone Morphogenetic Proteins; Osteocytes; Haversian System; Femur Neck; Aged