Journal article
A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus
- Abstract:
- Neurogenesis continues through the adult life of mice in the subgranular zone of the dentate gyrus in the hippocampus, but its function remains unclear. Measuring cellular proliferation in the hippocampus of 719 outbred heterogeneous stock mice revealed a highly significant correlation with the proportions of CD8+ versus CD4+ T lymphocyte subsets. This correlation reflected shared genetic loci, with the exception of the H-2Ea locus that had a dominant influence on T cell subsets but no impact on neurogenesis. Analysis of knockouts and repopulation of TCRα-deficient mice by subsets of T cells confirmed the influence of T cells on adult neurogenesis, indicating that CD4+ T cells or subpopulations thereof mediate the effect. Our results reveal an organismal impact, broader than hitherto suspected, of the natural genetic variation that controls T cell development and homeostasis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 534.4KB, Terms of use)
-
- Publisher copy:
- 10.1371/journal.pbio.1000561
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS Biology More from this journal
- Volume:
- 8
- Issue:
- 12
- Pages:
- ARTN e1000561
- Publication date:
- 2010-12-14
- Acceptance date:
- 2010-10-28
- DOI:
- EISSN:
-
1545-7885
- ISSN:
-
1544-9173
- Language:
-
English
- Keywords:
- UUID:
-
uuid:67975230-a3e0-4528-8b1b-1e8a3318824a
- Local pid:
-
pubs:107081
- Source identifiers:
-
107081
- Deposit date:
-
2012-12-19
Terms of use
- Copyright holder:
- Huang et al
- Copyright date:
- 2010
- Notes:
- Copyright: © 2010 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.There is a correction to this article at https://doi.org/10.1371/annotation/f4594c2b-b835-4e1a-a7d6-8f2e58f60be5
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record