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Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis.

Abstract:

Foot-and-mouth disease virus (FMDV) VP1 G-H loop contains the major antigenic site. By replacing the sequence upstream of the RGD motif with a FLAG epitope, a marker virus for pathogenesis studies was generated. In cell culture, the recombinant virus containing FLAG (A24-FLAG) exhibited similar plaque phenotypes and growth kinetics to parental virus. A24-FLAG was distinguished, neutralized, and immunoprecipitated by FLAG anti-sera. A24-FLAG infected cattle exhibited FMD and an antibody respon...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2012.11.001

Authors


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Journal:
Virology
Volume:
436
Issue:
1
Pages:
150-161
Publication date:
2013-02-01
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
Source identifiers:
449397
Language:
English
Keywords:
Pubs id:
pubs:449397
UUID:
uuid:678fa393-cc62-4955-b60a-abcdfac36b0d
Local pid:
pubs:449397
Deposit date:
2014-02-24

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