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Polynucleotide phosphorylase activity may be modulated by metabolites in Escherichia coli

Abstract:

RNA turnover is an essential element of cellular homeostasis and response to environmental change. Whether the ribonucleases that mediate RNA turnover can respond to cellular metabolic status is an unresolved question. Here we present evidence that the Krebs cycle metabolite citrate affects the activity of Escherichia coli polynucleotide phosphorylase (PNPase) and, conversely, that cellular metabolism is affected widely by PNPase activity. An E. coli strain that requires PNPase for viability ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M110.200741

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of Biological Chemistry More from this journal
Volume:
286
Issue:
16
Pages:
14315-14323
Publication date:
2011-01-14
Acceptance date:
2011-01-14
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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