Investigation of the role of ANKH in ankylosing spondylitis.

Journal article

OBJECTIVE: The ank/ank mouse develops a phenotype similar to ankylosing spondylitis (AS) in humans. ANKH, the human homolog of the mutated gene in the ank/ank mouse, has been implicated in familial autosomal-dominant chondrocalcinosis and autosomal-dominant craniometaphyseal dysplasia. This study was undertaken to investigate the role of ANKH in susceptibility to and clinical manifestations of AS. METHODS: Sequence variants were identified by genomic sequencing of the 12 ANKH exons and their...

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Authors: Timms, A; Zhang, Y; Bradbury, L; Wordsworth, B; Brown, M

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 48
• Issue: 10
• Pages: 2898-2902
• Publication date: 2003-10-01
• DOI: 10.1002/art.11258
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Humans; Membrane Proteins; Adult; Phosphate Transport Proteins; Female; Genetic Predisposition to Disease; Genotype; Spondylitis, Ankylosing; Genetic Linkage; Polymorphism, Genetic; Male; Gene Frequency; Phenotype