Journal article

Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases

Abstract:: 2-Acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc], prepared in 20% overall yield from d-glucuronolactone, is the first potent competitive sub-micromolar inhibitor of α-N-acetyl-galactosaminidases (Ki 0.081 μM from chicken liver, Ki 0.136 μM from Charonia lampas). DGJNAc is a good competitive-whereas the enantiomer l-DGJNAc is a very weak but non-competitive-inhibitor of β-hexosaminidases. © 2010.

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APA Style

Best, D., Chairatana, P., Glawar, A., Crabtree, E., Butters, T., Wilson, F., Yu, C., Wang, W., Jia, Y., Adachi, I., Kato, A., & Fleet, G. (2010). Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases. Tetrahedron Letters, 51(17), 2222–2224.

MLA Style

Best, D., et al. “Synthesis of 2-Acetamido-1,2-Dideoxy-d-Galacto-Nojirimycin [DGJNAc] from d-Glucuronolactone: the First Sub-Micromolar Inhibitor of α-N-Acetylgalactosaminidases.” Tetrahedron Letters, vol. 51, no. 17, 2010, pp. 2222–24.

Chicago Style

Best, D, P Chairatana, A Glawar, E Crabtree, T Butters, F Wilson, C Yu, et al. 2010. “Synthesis of 2-Acetamido-1,2-Dideoxy-d-Galacto-Nojirimycin [DGJNAc] from d-Glucuronolactone: the First Sub-Micromolar Inhibitor of α-N-Acetylgalactosaminidases.” Tetrahedron Letters 51 (17): 2222–24.
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Publisher copy:: 10.1016/j.tetlet.2010.02.063

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+ Best, D More by this author

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+ Chairatana, P More by this author

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+ Glawar, A More by this author

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+ Crabtree, E More by this author

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+ Butters, T More by this author

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Journal:: Tetrahedron Letters More from this journal
Volume:: 51
Issue:: 17
Pages:: 2222-2224
Publication date:: 2010-04-28
DOI:: 10.1016/j.tetlet.2010.02.063
ISSN:: 0040-4039

Language:: English
Pubs id:: pubs:101142
UUID:: uuid:677b9294-758a-4bbe-9400-aed2c8cad01c
Local pid:: pubs:101142
Source identifiers:: 101142
Deposit date:: 2012-12-19

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Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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