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Control of experimental inflammatory bowel disease by regulatory T cells

Abstract:

A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in ...

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Publication status:
Published

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Volume:
162
Issue:
4
Pages:
S185-+
Publication date:
2000-10-05
ISSN:
1073-449X
URN:
uuid:6774fb70-aa66-465c-a22f-da6cc4291d17
Source identifiers:
10934
Local pid:
pubs:10934

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