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Control of experimental inflammatory bowel disease by regulatory T cells

Abstract:

A helper T cell type 1-mediated colitis driven by enteric bacteria develops in severe combined immunodeficient mice after transfer of CD45RB(high)CD4(+) T cells. Development of disease can be prevented by cotransfer of the reciprocal CD45RB(low) subset. Analysis of the mechanism of immune suppression transferred by CD45RB(low)CD4(+) cells revealed essential roles for both IL-10 and TGF-beta. These data indicate that a functionally specialized population of regulatory T (Treg) cells exists in ...

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Publication status:
Published

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Journal:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume:
162
Issue:
4
Pages:
S185-+
Publication date:
2000-10-01
Event title:
15th Annual Transatlantic Airway Conference
ISSN:
1073-449X
Source identifiers:
10934
Keywords:
Pubs id:
pubs:10934
UUID:
uuid:6774fb70-aa66-465c-a22f-da6cc4291d17
Local pid:
pubs:10934
Deposit date:
2012-12-19

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