Journal article : Review
Technology to the rescue: how to uncover the role of transposable elements in preimplantation development
- Abstract:
- Transposable elements (TEs) are highly expressed in preimplantation development. Preimplantation development is the phase when the cells of the early embryo undergo the first cell fate choice and change from being totipotent to pluripotent. A range of studies have advanced our understanding of TEs in preimplantation, as well as their epigenetic regulation and functional roles. However, many questions remain about the implications of TE expression during early development. Challenges originate first due to the abundance of TEs in the genome, and second because of the limited cell numbers in preimplantation. Here we review the most recent technological advancements promising to shed light onto the role of TEs in preimplantation development. We explore novel avenues to identify genomic TE insertions and improve our understanding of the regulatory mechanisms and roles of TEs and their RNA and protein products during early development.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1042/bst20231262
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 213612/A/18/Z
+ Biotechnology and Biological Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/00cwqg982
- Publisher:
- Portland Press
- Journal:
- Biochemical Society Transactions More from this journal
- Volume:
- 52
- Issue:
- 3
- Pages:
- 1349-1362
- Place of publication:
- England
- Publication date:
- 2024-05-16
- Acceptance date:
- 2024-04-24
- DOI:
- EISSN:
-
1470-8752
- ISSN:
-
0300-5127
- Pmid:
-
38752836
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1998154
- Local pid:
-
pubs:1998154
- Deposit date:
-
2024-10-21
Terms of use
- Copyright holder:
- Deaville and Berrens
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of University of Oxford in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.
- Licence:
- CC Attribution (CC BY)
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