Journal article
Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
- Abstract:
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We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immune tolerance in this model have remained unclear.We utilize the NOD.Foxp3hCD2 reporter mouse line and an ablative anti-hCD2 antibody to ask if CD4+FOXP3+ regulatory T cells (Treg) are required for coreceptor and costi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.1MB)
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- Publisher copy:
- 10.1186/s13073-018-0581-y
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Authors
Funding
Croucher Foundation
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Lui Chi Woo Institute of Innovative Medicine
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Genome Medicine Journal website
- Volume:
- 71
- Issue:
- 10
- Publication date:
- 2018-09-20
- Acceptance date:
- 2018-09-07
- DOI:
- EISSN:
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1756-994X
- ISSN:
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1756-994X
- Pmid:
-
30236153
- Source identifiers:
-
923322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:923322
- UUID:
-
uuid:675fe3d0-bc39-4c14-a8c5-c4eb86f110be
- Local pid:
- pubs:923322
- Deposit date:
- 2018-11-07
Terms of use
- Copyright holder:
- Leung et al
- Copyright date:
- 2018
- Notes:
- © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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