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Journal article

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Abstract:

We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immune tolerance in this model have remained unclear.We utilize the NOD.Foxp3hCD2 reporter mouse line and an ablative anti-hCD2 antibody to ask if CD4+FOXP3+ regulatory T cells (Treg) are required for coreceptor and costi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s13073-018-0581-y

Authors


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Croucher Foundation More from this funder
Lui Chi Woo Institute of Innovative Medicine More from this funder
Publisher:
BMC Publisher's website
Journal:
Genome Medicine Journal website
Volume:
71
Issue:
10
Publication date:
2018-09-20
Acceptance date:
2018-09-07
DOI:
EISSN:
1756-994X
ISSN:
1756-994X
Pubs id:
pubs:923322
URN:
uri:675fe3d0-bc39-4c14-a8c5-c4eb86f110be
UUID:
uuid:675fe3d0-bc39-4c14-a8c5-c4eb86f110be
Local pid:
pubs:923322

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