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Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Abstract:

We have previously reported an antigen-specific protocol to induce transplant tolerance and linked suppression to human embryonic stem cell (hESC)-derived tissues in immunocompetent mice through coreceptor and costimulation blockade. However, the exact mechanisms of acquired immune tolerance in this model have remained unclear.We utilize the NOD.Foxp3hCD2 reporter mouse line and an ablative anti-hCD2 antibody to ask if CD4+FOXP3+ regulatory T cells (Treg) are required for coreceptor and costi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
Health and Medical Research Fund
Grant:
04152566
More from this funder
Name:
Research Grants Council of Hong Kong
Grant:
C4026-17WF
More from this funder
Name:
Lui Chi Woo Institute of Innovative Medicine
Publisher:
BioMed Central
Journal:
Genome Medicine More from this journal
Volume:
71
Issue:
10
Publication date:
2018-09-20
Acceptance date:
2018-09-07
DOI:
EISSN:
1756-994X
ISSN:
1756-994X
Pmid:
30236153
Language:
English
Keywords:
Pubs id:
pubs:923322
UUID:
uuid:675fe3d0-bc39-4c14-a8c5-c4eb86f110be
Local pid:
pubs:923322
Source identifiers:
923322
Deposit date:
2018-11-07

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