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Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.

Abstract:

Bruton's tyrosine kinase (Btk), the gene mutated in the human immunodeficiency X-linked agammaglobulinemia, is activated by LPS and is required for LPS-induced TNF production. In this study, we have investigated the role of Btk both in signaling via another TLR (TLR2) and in the production of other proinflammatory cytokines such as IL-1beta, IL-6, and IL-8. Our data show that in X-linked agammaglobulinemia PBMCs, stimulation with TLR4 (LPS) or TLR2 (N-palmitoyl-S-[2, 3-bis(palmitoyloxy)-(2R)-...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.6.3635

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Journal:
Journal of Immunology
Volume:
176
Issue:
6
Pages:
3635-3641
Publication date:
2006-03-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
223508

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