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Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma.

Abstract:

Epithelial-to-mesenchymal transition (EMT), in which epithelial cells loose their polarity and become motile mesenchymal cells, is a determinant of melanoma metastasis. We compared gene expression signatures of mesenchymal-like melanoma cells with those of epithelial-like melanoma cells, and identified Thrombospondin 1 (THBS1) as highly up-regulated in the mesenchymal phenotype. This study investigated whether THBS1, a major physiological activator of transforming growth factor (TGF)-beta, is...

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Publisher:
Impact Journals LLC
Journal:
Oncotarget
Volume:
5
Issue:
14
Pages:
5782-5797
Publication date:
2014-07-05
EISSN:
1949-2553
URN:
uuid:675648d0-3cfb-42e7-94fd-e3158bd3af3c
Source identifiers:
477453
Local pid:
pubs:477453

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