Journal article
Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma.
- Abstract:
-
Epithelial-to-mesenchymal transition (EMT), in which epithelial cells loose their polarity and become motile mesenchymal cells, is a determinant of melanoma metastasis. We compared gene expression signatures of mesenchymal-like melanoma cells with those of epithelial-like melanoma cells, and identified Thrombospondin 1 (THBS1) as highly up-regulated in the mesenchymal phenotype. This study investigated whether THBS1, a major physiological activator of transforming growth factor (TGF)-beta, is...
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Bibliographic Details
- Publisher:
- Impact Journals LLC
- Journal:
- Oncotarget
- Volume:
- 5
- Issue:
- 14
- Pages:
- 5782-5797
- Publication date:
- 2014-07-05
- EISSN:
-
1949-2553
- URN:
-
uuid:675648d0-3cfb-42e7-94fd-e3158bd3af3c
- Source identifiers:
-
477453
- Local pid:
- pubs:477453
Item Description
- Language:
- English
- Keywords:
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- Copyright date:
- 2014
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