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Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat

Abstract:

Recent studies in prehypertensive spontaneously hypertensive rats (SHR) have shown larger calcium transients and reduced norepinephrine transporter (NET) activity in cultured stellate neurons compared with Wistar-Kyoto (WKY) controls, although the functional significance of these results is unknown. We hypothesized that peripheral sympathetic responsiveness in the SHR at 4 wk of age would be exaggerated compared with the WKY. In vivo arterial pressure (under 2% isoflurane) was similar in SHRs...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1152/ajpheart.00255.2013

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
British Heart Foundation
Funding agency for:
Herring, N
Shanks, J
Paterson, D
Publisher:
American Physiological Society
Journal:
American Journal of Physiology - Heart and Circulatory Physiology More from this journal
Volume:
305
Issue:
7
Pages:
H980-H986
Publication date:
2013-10-01
Acceptance date:
2013-07-30
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Language:
English
Keywords:
Pubs id:
pubs:416287
UUID:
uuid:671ea6b9-b83d-42a5-92d0-13365ae8c63f
Local pid:
pubs:416287
Source identifiers:
416287
Deposit date:
2013-11-16

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