Journal article

Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine.

Abstract:: An efficient enantioselective total synthesis of (R)-rolipram and an efficient enantioselective formal synthesis of (3S,4R)-paroxetine has been achieved using the highly enantioselective Michael addition of malonate nucleophiles as key steps in both cases.

Publication status:: Published

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APA Style

Hynes, P., Stupple, P., & Dixon, D. (2008). Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine. Organic Letters, 10(7), 1389–1391.

MLA Style

Hynes, P., et al. “Organocatalytic Asymmetric Total Synthesis of (R)-Rolipram and Formal Synthesis of (3S,4R)-Paroxetine.” Organic Letters, vol. 10, no. 7, 2008, pp. 1389–91.

Chicago Style

Hynes, P, P Stupple, and D Dixon. 2008. “Organocatalytic Asymmetric Total Synthesis of (R)-Rolipram and Formal Synthesis of (3S,4R)-Paroxetine.” Organic Letters 10 (7): 1389–91.
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Publisher copy:: 10.1021/ol800108u

Authors

+ Hynes, P More by this author

Role:: Author

+ Stupple, P More by this author

Role:: Author

+ Dixon, D More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Organic letters More from this journal
Volume:: 10
Issue:: 7
Pages:: 1389-1391
Publication date:: 2008-04-01
DOI:: 10.1021/ol800108u
EISSN:: 1523-7052
ISSN:: 1523-7060

Language:: English
Keywords:: Paroxetine

Stereoisomerism

Malonates

Catalysis

Rolipram

Molecular Structure
Pubs id:: pubs:34164
UUID:: uuid:67180482-180c-42fd-a94c-833cedba0c98
Local pid:: pubs:34164
Source identifiers:: 34164
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2008

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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