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Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine.

Abstract:
An efficient enantioselective total synthesis of (R)-rolipram and an efficient enantioselective formal synthesis of (3S,4R)-paroxetine has been achieved using the highly enantioselective Michael addition of malonate nucleophiles as key steps in both cases.
Publication status:
Published

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Publisher copy:
10.1021/ol800108u

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Organic letters More from this journal
Volume:
10
Issue:
7
Pages:
1389-1391
Publication date:
2008-04-01
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Language:
English
Keywords:
Pubs id:
pubs:34164
UUID:
uuid:67180482-180c-42fd-a94c-833cedba0c98
Local pid:
pubs:34164
Source identifiers:
34164
Deposit date:
2012-12-19

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