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Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases.

Abstract:

Tissue inflammation results in the production of numerous reactive oxygen, nitrogen and chlorine species, in addition to the products of lipid and sugar oxidation. Some of these products are capable of chemically modifying amino acids. This in turn results in changes to the structure and function of proteins. Increasing evidence demonstrates that such oxidative post-translational modifications result in the generation of neo-epitopes capable of eliciting both innate and adaptive immune respon...

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Publisher copy:
10.1016/j.redox.2014.05.004

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Elsevier
Journal:
Redox biology
Volume:
2
Issue:
1
Pages:
715-724
Publication date:
2014-01-01
DOI:
EISSN:
2213-2317
ISSN:
2213-2317
Language:
English
Pubs id:
pubs:471714
UUID:
uuid:67073d94-4755-475f-b8e3-2943c7da88e4
Local pid:
pubs:471714
Source identifiers:
471714
Deposit date:
2014-10-31

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