Journal article
Spatiotemporally super-resolved volumetric traction force microscopy
- Abstract:
- Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measurements are essential to understanding the role of biomechanics in cell regulation and function. Traction force microscopy remains the most broadly applied force probing technology but typically restricts itself to single-plane two-dimensional quantifications with limited spatiotemporal resolution. Here, we introduce an enhanced force measurement technique combining 3D super-resolution fluorescence structural illumination microscopy and traction force microscopy (3D-SIM-TFM) offering increased spatiotemporal resolution, opening-up unprecedented insights into physiological three-dimensional force production in living cells.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.5MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.nanolett.9b01196
Authors
- Publisher:
- American Chemical Society
- Journal:
- Nano Letters More from this journal
- Volume:
- 19
- Issue:
- 7
- Pages:
- 4427-4434
- Publication date:
- 2019-06-14
- Acceptance date:
- 2019-06-12
- DOI:
- EISSN:
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1530-6992
- ISSN:
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1530-6984
- Pmid:
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31199151
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1015646
- UUID:
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uuid:67027259-66ac-4fbc-9afc-cad6f15e0ce0
- Local pid:
-
pubs:1015646
- Source identifiers:
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1015646
- Deposit date:
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2019-08-07
- ARK identifier:
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Notes:
-
© 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium,
provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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