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The role of the C-terminus of SUR in the differential regulation of beta-cell and cardiac KATP channels by MgADP and metabolism

Abstract:

ATP‐sensitive potassium (KATP) channels couple the metabolic state of a cell to its electrical activity and play important physiological roles in many tissues. In contrast to β‐cell (Kir6.2/SUR1) channels, which open when extracellular glucose levels fall, cardiac (Kir6.2/SUR2A) channels remain closed. It is known this is due to differences in the SUR subunit rather than cell metabolism. As ATP inhibition and MgADP activation are similar for both types of channels, we investigated channel inh...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1113/JP276708

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Trinity College
Role:
Author
ORCID:
0000-0002-6970-1767
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
Royal Society More from this funder
Publisher:
John Wiley & Sons, Inc Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
596
Issue:
24
Pages:
6205-6217
Publication date:
2018-09-04
Acceptance date:
2018-08-29
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pubs id:
pubs:911171
URN:
uri:66ce84c4-5e3e-4c91-9fc6-2313add30038
UUID:
uuid:66ce84c4-5e3e-4c91-9fc6-2313add30038
Local pid:
pubs:911171

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