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Transcriptomic signatures in sepsis and a differential response to steroids: from the VANISH randomized trial

Abstract:
Rationale: There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration but conflicting survival effects. Two transcriptomic sepsis response signatures (SRS) have been identified. SRS1 is relatively immunosuppressed whilst SRS2 is relatively immunocompetent. Objectives: We aimed to categorized patients based on SRS endotypes to determine if these profiles influenced response to either norepinephr... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1164/rccm.201807-1419oc

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Role:
Author
ORCID:
0000-0002-1846-9160
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0001-8680-2933
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Grant:
Research for Patient Benefit program (Grant number PB-PG-0610-22350
NIHR Clinician Scientist Award (NIHR/CS/009/007)
NIHR Research Professor award (RP-2015-06-018) held by Prof Gordon
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Grant:
090532/Z/09/Z
Investigator Award (204969/Z/16/Z ) to Prof Knight
Publisher:
American Thoracic Society Publisher's website
Journal:
American Journal of Respiratory and Critical Care Medicine Journal website
Volume:
199
Issue:
8
Pages:
980–986
Publication date:
2018-10-26
Acceptance date:
2018-10-24
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
Pubs id:
pubs:935354
URN:
uri:66c7e18c-537f-4b44-9847-75ddf12d8dc5
UUID:
uuid:66c7e18c-537f-4b44-9847-75ddf12d8dc5
Local pid:
pubs:935354

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