- Abstract:
-
Objective A previous genome‐wide association study linked overexpression of an ATP‐binding cassette transporter, ABCC5, in humans with a susceptibility to developing type 2 diabetes with age. Specifically, ABCC5 gene overexpression was shown to be strongly associated with increased visceral fat mass and reduced peripheral insulin sensitivity. Currently, the role of ABCC5 in diabetes and obesity is unknown. This study reports the metabolic phenotyping of a global Abcc5 knockou... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.8MB)
-
- Publisher copy:
- 10.1002/oby.22521
-
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- Funding agency for:
- Cyranka, M
- Publisher:
- Wiley Publisher's website
- Journal:
- Obesity Journal website
- Volume:
- 27
- Issue:
- 8
- Pages:
- 1292-1304
- Publication date:
- 2019-07-24
- Acceptance date:
- 2019-04-09
- DOI:
- EISSN:
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1930-739X
- ISSN:
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1930-7381
- Pubs id:
-
pubs:1036789
- URN:
-
uri:66a660c8-b712-4a61-afb9-64ba64aa795f
- UUID:
-
uuid:66a660c8-b712-4a61-afb9-64ba64aa795f
- Local pid:
- pubs:1036789
- Language:
- English
- Copyright holder:
- Cyranka et al.
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS). This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Abcc5 knockout mice have lower fat mass and increased levels of circulating GLP‐1
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