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Abcc5 knockout mice have lower fat mass and increased levels of circulating GLP‐1

Abstract:
Objective A previous genome‐wide association study linked overexpression of an ATP‐binding cassette transporter, ABCC5, in humans with a susceptibility to developing type 2 diabetes with age. Specifically, ABCC5 gene overexpression was shown to be strongly associated with increased visceral fat mass and reduced peripheral insulin sensitivity. Currently, the role of ABCC5 in diabetes and obesity is unknown. This study reports the metabolic phenotyping of a global Abcc5 knockou... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/oby.22521

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
St Catherine's College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Lincoln College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Cyranka, M
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Funding agency for:
Cyranka, M
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Funding agency for:
Veprik, A
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Funding agency for:
Cantley, J
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Publisher:
Wiley Publisher's website
Journal:
Obesity Journal website
Volume:
27
Issue:
8
Pages:
1292-1304
Publication date:
2019-07-24
Acceptance date:
2019-04-09
DOI:
EISSN:
1930-739X
ISSN:
1930-7381
Pubs id:
pubs:1036789
URN:
uri:66a660c8-b712-4a61-afb9-64ba64aa795f
UUID:
uuid:66a660c8-b712-4a61-afb9-64ba64aa795f
Local pid:
pubs:1036789
Language:
English

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