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Isoniazid preventive therapy added to ART to prevent TB: an individual participant data meta-analysis

Abstract:

Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin test, and a non-significant effect on mortality. We aimed to estimate the effect of isoniazid preventive therapy given with antiretroviral therapy (ART) for the prevention of tuberculosis and death among people with HIV across population subgroups.

Methods:

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S2352-3018(20)30299-X

Authors

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-0412-8509


Publisher:
Elsevier
Journal:
Lancet HIV More from this journal
Volume:
8
Issue:
1
Pages:
E8-E15
Publication date:
2021-01-01
Acceptance date:
2020-10-14
DOI:
EISSN:
2352-3018
ISSN:
2405-4704


Language:
English
Keywords:
Pubs id:
1138057
Local pid:
pubs:1138057
Deposit date:
2020-10-17
ARK identifier:

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