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A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

Abstract:
An intercellular adhesion molecule-1 polymorphism (ICAM-1^Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1^Kilifi. We propose that ICAM-1^Kilifi may be associated with reduced rates of tissue damage and death due to sepsis.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1086/498156

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Institution:
"Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya", "Liverpool School of Tropical Medicine, Liverpool"
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Institution:
"Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya"
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Institution:
"Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya"
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Institution:
"Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - NDM John Radcliffe
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Institution:
"Liverpool School of Tropical Medicine, Liverpool"
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Funding agency for:
Neil E. Jenkins
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Funding agency for:
Alister G. Craig
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Funding agency for:
Thomas N. Williams
Publisher:
University of Chicago Press
Journal:
Clinical Infectious Diseases Journal website
Volume:
41
Issue:
12
Pages:
1817-1819
Publication date:
2005-12-05
DOI:
ISSN:
1058-4838
URN:
uuid:66877269-223c-444a-b171-fbc8341fc204
Local pid:
ora:2966

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