A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children
- An intercellular adhesion molecule-1 polymorphism (ICAM-1^Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1^Kilifi. We propose that ICAM-1^Kilifi may be associated with reduced rates of tissue damage and death due to sepsis.
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Copyright holder:
- Infectious Diseases Society of America
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- Citation: Jenkins, N. E. et al. (2005). 'A polymorphism of intercellular adhesion molecule–1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children', Clinical Infectious Diseases, 41(12), 1817-1819. [Available at http://www.journals.uchicago.edu/toc/cid].
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