Journal article
A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children
- Abstract:
- An intercellular adhesion molecule-1 polymorphism (ICAM-1^Kilifi) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1^Kilifi. We propose that ICAM-1^Kilifi may be associated with reduced rates of tissue damage and death due to sepsis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 77.2KB, Terms of use)
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- Publisher copy:
- 10.1086/498156
Authors
+ Wellcome Trust
More from this funder
- Funding agency for:
- Jenkins, N
- Craig, A
- Williams, T
- Grant:
- GR066684MF
- 066742
- 052595
- Publisher:
- University of Chicago Press
- Journal:
- Clinical Infectious Diseases More from this journal
- Volume:
- 41
- Issue:
- 12
- Pages:
- 1817-1819
- Publication date:
- 2005-12-01
- Edition:
- Publisher's version
- DOI:
- ISSN:
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1058-4838
- Language:
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English
- Keywords:
- Subjects:
- UUID:
-
uuid:66877269-223c-444a-b171-fbc8341fc204
- Local pid:
-
ora:2966
- Deposit date:
-
2009-09-15
- ARK identifier:
Terms of use
- Copyright holder:
- Infectious Diseases Society of America
- Copyright date:
- 2005
- Notes:
- Citation: Jenkins, N. E. et al. (2005). 'A polymorphism of intercellular adhesion molecule–1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children', Clinical Infectious Diseases, 41(12), 1817-1819. [Available at http://www.journals.uchicago.edu/toc/cid].
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