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Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

Abstract:

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic ac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41398-018-0199-2

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Balliol College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
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Publisher:
Springer Nature Publisher's website
Journal:
Translational Psychiatry Journal website
Volume:
154
Issue:
8
Pages:
Article: 154
Publication date:
2018-08-14
Acceptance date:
2018-06-11
DOI:
EISSN:
2158-3188
Pubs id:
pubs:891595
URN:
uri:66486561-4508-4c73-a727-18ff3498f97f
UUID:
uuid:66486561-4508-4c73-a727-18ff3498f97f
Local pid:
pubs:891595

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