Conference item
Mechanistic pathways underlying altered neurovascular coupling in brain metastasis
- Abstract:
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Objectives: It is recognised that astrocytes form a physical bridge between neurons and the cerebrovasculature. Astrocytic end-feet help maintain endothelial tight junctions to support the blood–brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. In secondary cancer (metastasis) to the brain, astrocytes are displaced from the vasculature and become activated, and we have shown that neurovascular coupling is compromised in rat model of brain metastasis (Serres et ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 369.9KB, Terms of use)
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- Publisher copy:
- 10.1177/0271678X16639008
Authors
- Publisher:
- SAGE Publications
- Host title:
- Journal of Cerebral Blood Flow and Metabolism
- Journal:
- Journal of Cerebral Blood Flow and Metabolism More from this journal
- Volume:
- 36
- Issue:
- 1_suppl
- Pages:
- 540-541
- Publication date:
- 2016-06-01
- DOI:
- EISSN:
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1559-7016
- ISSN:
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0271-678X
- Keywords:
- Pubs id:
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pubs:716192
- UUID:
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uuid:6642e042-f06c-447d-a9f4-2abe22b47b59
- Local pid:
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pubs:716192
- Source identifiers:
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716192
- Deposit date:
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2018-10-30
- ARK identifier:
Terms of use
- Copyright holder:
- Sarmiento Soto
- Copyright date:
- 2016
- Notes:
- © The Authors 2016.
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